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Paris, France, and Cambridge, Mass., United States, October 05, 2020 – Eyevensys, a privately held, clinical-stage biotechnology company developing non-viral gene therapies for ophthalmic diseases, today announced the U.S. Food and Drug Administration (FDA) has granted an orphan-drug designation (ODD) for EYS611 for the treatment of retinitis pigmentosa (RP).  

Eyevensys is developing EYS611, a DNA plasmid that encodes for the human transferrin protein, to benefit patients diagnosed with RP, as well as other degenerative retinal diseases, including late stage, dry age-related macular degeneration and glaucoma.  

Transferrin is an endogenous protein that helps manage iron levels in the eye. While iron is essential for retinal metabolism and the visual cycle, excessive iron can induce oxidative stress and is extremely toxic to the retina. Iron overload has been associated with photoreceptor death in several retinal degenerative diseases. By acting as an iron chelating and neuroprotective agent, EYS611 helps slow the progression of diseases like RP regardless of the specific genetic mutation causing the condition.  

Eyevensys just reported data from preclinical testing in the September 2020 issue of the journal Pharmaceutics. The paper, entitled “Transferrin non-viral gene therapy for treatment of retinal degeneration” (Bigot, et al., Pharmaceutics), shows that EYS611 is safe and effective for preserving photoreceptors and retina functionality in acute toxicity and inherited rat models of retinal degeneration. 

“We are delighted to have received orphan-drug designation from the FDA as it is an important regulatory milestone. We look forward to translating our unique non-viral gene therapy program to patients with RP, to slow the progression of this degenerative retinal disease with no currently approved treatment that compromises patients’ vision and eventually lead to blindness,” said Thierry Bordet, PhD, Chief Scientific Officer.  

“This orphan-drug designation acknowledges the unmet needs of individuals suffering from RP, and this opportunity to move our therapy through the development process with this designation is an encouraging milestone. With EYS611, we are optimistic we will advance a therapeutic option for all patients with RP independent of the underlying genetic mutation that is much less invasive and can be used to treat patients at an earlier stage of disease than traditional viral vector gene replacement therapies that target only the macula and are being developed only for a select handful of RP patients with specific mutations,” said Ronald Buggage, MD, Eyevensys’ Chief Medical Officer.  

The FDA’s Orphan Drug Designation Program provides orphan status to drugs and biologics that are defined as those intended for the safe and effective treatment, diagnosis or prevention of rare diseases/disorders that affect fewer than 200,000 people in the U.S., or that affect more than 200,000 persons but are not expected to recover the costs of developing and marketing a treatment drug.  

About Eyevensys 

Eyevensys is a privately held, clinical-stage biotechnology company developing its innovative technology to enable the sustained intraocular production of therapeutic proteins to treat a broad range of ophthalmic diseases. 

The Eyevensys technology, developed by Pr. Francine Behar-Cohen, uses electroporation to deliver proprietary DNA plasmids encoding therapeutic proteins into the ciliary muscle of the eye. This approach induces the sustained intraocular production of therapeutic proteins. 

Eyevensys’ lead product EYS606 is a potential new treatment for patients with chronic non-infectious uveitis (NIU). EYS606 combines Eyevensys’ proprietary Electrotransfection System with plasmids encoding for the production of a potent fusion protein which neutralizes the activity of TNFα, a cytokine that has been shown to play a pivotal role in mediating intraocular inflammation in NIU. EYS606 is currently in a phase I/II clinical trial in the EU and has been granted an Orphan drug designation by the European Medicines Agency (EMA) for the treatment of NIU. The therapeutic potential of EYS606 in patients with active, chronic NIU is being further investigated in Part 2 of the ongoing EYS606-CT1 study in the EU and in a second phase 2 trial, the Electro Study (EYS606-CT2) being conducted in the US. 

Additionally, Eyevensys is developing EYS611, a treatment for Retinitis Pigmentosa and potentially other retinal degenerative conditions including the later stages of Dry AMD and glaucoma. The treatment encodes for a potent iron chelator with antioxidant and endogenous neuroprotective properties. In animal models, the treatment has been shown to be safe and effective at preserving and slowing the degeneration of retinal structure and function. 

Eyevensys is also advancing a dual gene plasmid, EYS809, expressing two therapeutic proteins for wet AMD, diabetic macular edema, and central retinal vein occlusion, and it is exploring further compounds for undisclosed indications. 

Eyevensys was founded in 2008. The company has offices in Paris, France and the U.S. The company is funded by the Boehringer Ingelheim Venture Fund, Pureos Bioventures, Bpifrance through the Innobio Fund, CapDecisif, Inserm Transfert Initiative, Pontifax and the Global Health Sciences Fund. 

For more information about Eyevensys, please visit www.eyevensys.com. 

Media Relations Contact:
Marion Janic, RooneyPartners
[email protected]
+1-212-223-4017 

1. Gerald Cagle, Ph.D. named Chairman of the Board
2. Francine Behar-Cohen, M.D., Ph.D. named Chief Innovation Officer
3. Thierry Bordet, Ph.D. named Chief Scientific Officer

Paris, France, and Fort Worth, Texas, United States, March 10, 2020 – Eyevensys, a privately held clinical-stage biotechnology company developing non-viral gene therapies for ophthalmic diseases, today announced the expansion of its leadership team with the appointment of Gerald Cagle as the Board’s Chairman, Francine Behar-Cohen to Chief Innovation Officer and Thierry Bordet as the Chief Scientific Officer.

Dr. Cagle, who joined Eyevensys’ Board of Directors in 2018, was the former Senior Vice President and Chief Scientific Officer at Alcon Laboratories, the world’s largest eye care device company. He  will replace Dr. Garth Cumberlidge, the company’s current Chairman. Dr. Cagle will work closely with and advise Dr. Patricia Zilliox, Eyevensys’ CEO, in strategic decision making for the company.Dr. Cagle said, “I am looking forward to working even closer with the Eyevensys management team to help it achieve its next level of growth and I am truly honored to lead such an extraordinary Board as its Chairman.”

Eyevensys founder and previous Chief Scientific Officer, Pr. Behar-Cohen will assume the role of Chief Innovation Officer – a newly created position at the company. “Within the next 10 years, gene therapies will be accepted treatments for both rare genetic retinal conditions and more common eye diseases and patients will be able to have treatments based on their own specific genetic profiles. Eyevensys is at the forefront of creating technologies that will be best-in-class to treat and prophylactically prevent future ocular maladies,” Pr. Behar-Cohen said.    

Dr. Thierry Bordet has been promoted to Chief Scientific Officer, from his previous position as Pre-Clinical Director for the company. Prior to coming to Eyevensys in 2017, Dr. Bordet had over 15 years of experience in the biotechnology sector having managed drug development programs for small molecules, gene therapies, cell-based therapies and tissue engineered products. He was most recently Pre-Clinical Development Director at the Biotherapies Institute for Rare Diseases, in Evry, France where he designed development strategies for advanced therapy medicinal products for various indications, including inherited retinitis pigmentosa.

About Eyevensys

Eyevensys is a privately held, clinical-stage biotechnology company developing its innovative technology to enable the sustained intraocular production of therapeutic proteins to treat a broad range of ophthalmic diseases.

The Eyevensys technology, developed by Pr. Francine Behar-Cohen, uses electroporation to deliver improved proprietary DNA plasmids encoding therapeutic proteins into the ciliary muscle of the eye. This approach facilitates the sustained intraocular production of therapeutic proteins.

Eyevensys’ lead product EYS606 is a potential new treatment for patients with chronic non-infectious uveitis (CNIU). EYS606 combines Eyevensys’ proprietary Electrotransfection System with plasmids encoding for the production of a potent fusion protein which neutralizes the activity of TNFα, a cytokine that has been shown to play a pivotal role in mediating intraocular inflammation in NIU. EYS606 is currently in a phase I/II clinical trial in the EU and has been granted an Orphan drug designation by the European Medicines Agency (EMA) for the treatment of NIU. The therapeutic potential of EYS606 in patients with active, chronic NIU will be further investigated in Part 2 of the ongoing EYS606-CT1 study in the EU and in a second phase 2 trial, the Electro Study (EYS606-CT2) that will be launched in the U.S. in early 2020.

Additionally, Eyevensys is developing EYS611, a treatment for Retinitis Pigmentosa and later stages of Dry AMD. The treatment encodes for a potent iron chelator with antioxidant and endogenous neuroprotective properties. In animal models, the treatment has been shown to be safe and effective at preserving the retina in the wake of both conditions.

Eyevensys is also advancing a third compound, EYS809, for wet AMD, diabetic macular edema, and central retinal vein occlusion, and it is exploring further compounds for undisclosed indications.

Eyevensys was founded in 2008. It is headquartered in Paris, France, and operates a wholly-owned U.S. subsidiary out of Fort Worth, Texas. The company is funded by the Boehringer Ingelheim Venture Fund, Pureos Bioventures, Bpifrance through the Innobio Fund, CapDecisif, Inserm Transfert Initiative, Pontifax and the Global Health Sciences Fund.

For more information about Eyevensys please visit www.eyevensys.com.

Media Relations Contact:
Marion Janic, RooneyPartners
[email protected]
+1-212-223-4017 

Eyevensys announced today that it has completed a $30 million Series B financing. The round was led by Boehringer Ingelheim Venture Fund and included participation from existing investors Pontifax, Bpifrance, CapDecisif, and Inserm Transfert, as well as new investors, the Global Health Sciences (GHS) Fund (Quark Venture LP and GF Securities) and Pureos Bioventures. 

The company will use the funds to continue the development of its clinical lead candidate EYS606 for the treatment of chronic non-infectious uveitis (NIU), including the launch of its Electro Study. This Phase 2 trial, to be conducted in the U.S., will evaluate the safety and efficacy of EYS606 in patients with active forms of all anatomic uveitis subtypes. The funding will also advance the preclinical development of its other therapeutic proteins targeting ophthalmic diseases with unaddressed medical needs such as retinitis pigmentosa and age-related macular degeneration (AMD). EYS606 is currently in a phase I/II clinical trial in the EU and has been granted an Orphan drug designation by the European Medicines Agency (EMA) for the treatment of NIU. 

In conjunction with the financing, Eyevensys has added to its Board of Directors. Neena Kadaba, PhD, Director of Science at Quark Venture LP, joined the board, as well as Dominik Escher, PhD, Managing Partner at Pureos Bioventures, and former founder and CEO of ESBATech, an ophthalmology biotech company acquired by Alcon in 2009, which developed the recently approved Beovu, a new treatment for wet age-related macular degeneration. 

Eyevensys has also recently opened a wholly-owned U.S. subsidiary in Fort Worth, Texas. All U.S. operations will be managed from this location, though the Eyevensys headquarters will remain in Paris. 

The Eyevensys technology is a non-viral gene therapy ocular drug delivery platform that uses an Electrotransfection System to deliver DNA plasmids encoding therapeutic proteins into the ciliary muscle. This turns the eye into a biofactory, allowing the ciliary muscle to express and secrete the therapeutic protein to the back of the eye at therapeutic levels for a duration of greater than 6 months. 

Dr. Patricia Zilliox, Chief Executive Officer, said, “We are thrilled to have completed this Series B funding round with the strong support from both existing and new investors for the company. This funding will assist the further development of our technology and position Eyevensys as an innovator in the field of ophthalmology.” 

She continued: “As we launch the Electro Study, our first U.S. clinical trial, Eyevensys will also have an opportunity to connect with ophthalmology opinion leaders in the U.S. to gain further exposure for our groundbreaking technology platform. This will also move the company one step closer to providing a more effective and convenient treatment approach to ease the burden of managing patients with chronic ocular conditions.” 

About Eyevensys 

Eyevensys is a privately held, clinical-stage biotechnology company developing its innovative technology to enable the sustained intraocular production of therapeutic proteins to treat a broad range of ophthalmic diseases. 

The Eyevensys technology, developed by Dr. Francine Behar-Cohen in Paris, uses electroporation to deliver improved proprietary DNA plasmids encoding therapeutic proteins into the ciliary muscle of the eye. This approach facilitates the sustained intraocular production of therapeutic proteins. 

Eyevensys’ lead product EYS606 is a potential new treatment for patients with chronic non-infectious uveitis (NIU). EYS606 combines Eyevensys’ proprietary Electrotransfection System with plasmids encoding for the production of a potent fusion protein which neutralizes the activity of TNFα, a cytokine that has been shown to play a pivotal role in mediating intraocular inflammation in NIU. EYS606 is currently in a phase I/II clinical trial in the EU and has been granted an Orphan drug designation by the European Medicines Agency (EMA) for the treatment of NIU. The therapeutic potential of EYS606 in patients with active, chronic NIU will be further investigated in Part 2 of the ongoing EYS606-CT1 study in the EU and in a second phase 2 trial, the Electro Study (EYS606-CT2) that will be launched in the US in early 2020. 

Additionally, Eyevensys is developing EYS611, a treatment for Retinitis Pigmentosa and Dry AMD. The treatment encodes for a potent iron chelator with antioxidant and endogenous neuroprotective properties. In animal models, the treatment has been shown to be safe and effective at preserving the retina in the wake of both conditions. 

Eyevensys is also advancing a third compound, EYS609, for wet AMD, diabetic macular edema, and central retinal vein occlusion, and it is exploring further compounds for undisclosed indications. 

Eyevensys was founded in 2008. It is headquartered in Paris, France, and operates a wholly-owned U.S. subsidiary out of Fort Worth, Texas. The company is funded by the Boehringer Ingelheim Venture Fund, Pureos Bioventures, Bpifrance through the Innobio Fund, CapDecisif, Inserm Transfert Initiative, Pontifax and the Global Health Sciences Fund. 

For more information about Eyevensys please visit www.eyevensys.com. 

Media Relations Contact: 

Marion Janic, RooneyPartners 

[email protected]

+1-212-223-4017 

Eyevensys this week presented results from part 1 of its phase I/II study for non-infectious uveitis (NIU) at the Ophthalmology Innovation Summit’s (OIS) 11th Annual OIS@AAO conference on October 10, 2019 in San Francisco. Dr. Ronald R. Buggage, MD, Chief Medical Officer of Eyevensys, discussed the novel technology during the Gene & Cell Therapy Spotlight session. 

The company’s technology is a non-viral gene therapy ocular drug delivery platform that uses a two-part Electrotransfection System, including a proprietary Ocular Device and Electrical Pulse Generator, that delivers DNA plasmids encoding therapeutic proteins into the ciliary muscle. This turns the eye into a biofactory, allowing the ciliary muscle to produce the therapeutic protein. The secreted protein reaches the back of the eye, including the retina and choroid. 

Eyevensys has successfully completed Part 1 of a clinical safety study of its lead product EYS606, a non-viral vector encoding an anti-TNFα protein. Tumor necrosis factor alpha (TNFα) is a cytokine that has been shown to play a pivotal role in mediating intraocular inflammation. The trial enrolled nine patients (three patients per cohort) with late-stage, NIU in France and the U.K. The study revealed no serious adverse events related to the Eyevensys technology and the overall early safety profile was similar to that of other intraocularly administered ophthalmic treatments. 

Despite their advanced disease stage at enrollment three of the 9 patients treated with EYS606 showed clinical improvements lasting for six months after one administration of the treatment. The first patient treated in the lowest dose cohort experienced a >10 ETDRS letter improvement in best corrected visual acuity while two patients treated in the highest dose cohort showed a significant reduction of macular edema via optical coherence tomography (OCT) associated with at least +12 ETDRS letters increase in BCVA from baseline. 

An investigational new drug (IND) application was filed in July 2019 and subsequently cleared with the U.S. Food and Drug Administration in August 2019. This IND allows Eyevensys to further validate the technology in a phase II clinical study targeting patients with active chronic NIU. In parallel, Eyevensys is also advancing preclinical programs using different proteins for other ophthalmic diseases, including retinitis pigmentosa, dry AMD, glaucoma, macular edema associated with wet-AMD, DME, and CRVO. 

Dr. Buggage said, “We are extremely proud to reach this stage of development with our lead clinical candidate based on the Eyevensys technology. The potential to express a diversity of therapeutic proteins at effective intraocular concentrations sustained for over 6 months with our minimally invasive, non-viral gene therapy drug delivery platform will revolutionize the way we treat ocular diseases while reducing the burden of treatment for both patients and ophthalmologists.” 

Dr. Patricia Zilliox, Chief Executive Officer, said, “We’re pleased to have an opportunity to share these initial findings from our lead study with our peers and offer a glimpse into ongoing development at 

Eyevensys to date. With these results, we can continue to move forward with our strategy to introduce our proprietary technology, the Electrotransfection System, into the treatment paradigm to improve long-term therapeutic outcomes.” 

About Eyevensys 

Eyevensys is a private clinical stage biotechnology company developing its innovative technology to enable the sustained intraocular production of therapeutic proteins to treat a broad range of ophthalmic diseases. 

The Eyevensys technology, developed by Dr. Francine Behar-Cohen in Paris, uses electroporation to deliver improved proprietary DNA plasmids encoding therapeutic proteins into the ciliary muscle of the eye. This approach facilitates the sustained intra-ocular production of therapeutic proteins. 

Eyevensys’ lead product EYS606 is a potential new treatment for patients with chronic non-infectious Uveitis (NIU). EYS606 combines Eyevensys’ proprietary Electrotransfection System with plasmids encoding for the production of a potent fusion protein which neutralizes the activity of TNFα, a cytokine that has been shown to play a pivotal role in mediating intraocular inflammation in NIU. EYS606 is currently in a phase I/II clinical trial in the EU and has been granted an Orphan drug designation by the European Medicines Agency (EMA) for the treatment of NIU. The therapeutic potential of EYS606 in patients with active, chronic NIU will be further investigated in Part 2 of the ongoing EYS606-CT1 study in the EU and in the Phase 2 EYS606-CT2 (Electro) Study that will be launched in the US in early 2020. 

Eyevensys was founded in 2008. It is headquartered in Paris, France, incorporated in the U.S., and is funded by Boehringer Ingelheim Venture Fund, BPIFrance, CapDecisif, Inserm Transfert, Pontifax and GHS. 

For more information about Eyevensys please visit www.eyevensys.com. 

Media Relations Contact: 

Marion Janic, RooneyPartners 

[email protected]

+1-212-223-4017

Eyevensys today announced that Gerald (Jerry) Cagle, Ph.D., former Senior Vice President and Chief Scientific Officer at Alcon Laboratories has joined its Board  of Directors.

Dr. Cagle is a highly respected pharmaceutical executive with managerial, technical and business experience spanning almost 40 years. Dr. Cagle served in key leadership roles for Alcon Laboratories Inc., including positions in clinical research, regulatory affairs, and product development. During the last 13 years at Alcon, he held the position of Senior Vice President and Chief Scientific Officer, introducing a range of new products. Dr. Cagle holds 28 issued patents in both drug and device areas and has published numerous scientific articles. More recently, he has served on the Boards of several life sciences companies.

Dr. Patricia Zilliox, CEO of Eyevensys, stated: “I am excited to welcome Dr. Cagle to our Board of Directors. His extensive wealth of product development and industry experience will be key to leverage our unique EyeCET platform. We expect Jerry’s expertise to be valuable as we further progress our lead product EYS606, currently in a Phase I/II clinical trial for the potential treatment of non-infectious uveitis (NIU).”

Dr. Gerald Cagle said: “I am delighted to join Eyevensys’ Board and look forward to working with a strong team and unlock the potential of its pioneering ocular drug delivery technology. The EyeCET technology is a very promising approach to address the deficiencies of current therapies for the treatment of a range of eye diseases. I look forward to contributing to the preclinical and clinical development efforts. ”

Paris (France), December 12th, 2017 – Eyevensys, a clinical stage biotech company developing non-viral gene therapies for ophthalmic diseases, today announced the appointment of Dr. Patricia Zilliox as CEO.

Dr. Zilliox, who joined the Eyevensys board in May 2016, has more than 25 years of global clinical development expertise. She previously served as Chief Drug Development Officer of the Clinical Research Institute, a division of the Foundation Fighting Blindness, in Columbia, MD, USA. From late 2008 until May 2011, Dr. Zilliox was head of clinical development at Alcon Laboratories, managing clinical development programs in areas of eye diseases such as glaucoma, allergy, dry eye, infectious diseases of the eye, and retinal diseases such as dry- and wet-AMD. Dr. Zilliox previously worked for Alcon in Paris, France, where she was responsible for the execution of Alcon’s European ophthalmology clinical trials.

Garth Cumberlidge, Chairman of Eyevensys’ Board, said, “I am delighted that Patricia has agreed to become the Company’s new CEO. Patricia’s strong clinical development experience in the field of ophthalmology together with her expertise at the Foundation Fighting Blindness will be important assets in building significant value for Eyevensys and its unique proprietary EyeCET technology. I am confident in Patricia’s ability to enhance and execute the company’s strategic plan to bring new medicines to market and create value for the Company’s shareholders.”

Garth added, “On behalf of Eyevensys board, I would also like to take this opportunity to thank Raffy Kazandjian for nurturing Eyevensys from its formative days to a clinical stage company.”

Dr. Patricia Zilliox stated: “It is a pleasure to become the CEO of a company I already know well and one that combines world-class scientific innovation, unique technology with significant commercial potential and a team of experts in the field of ophthalmology who are committed to bringing innovative products to ophthalmic patients. I am looking forward to leading our efforts to further the clinical development of our lead product EYS606 and to develop a strong portfolio of proprietary products to treat major ophthalmic diseases leveraging our unique EyeCET platform.”

Paris (France), 13th September 2017 – Eyevensys, a clinical stage biotech company developing its proprietary EyeCET platform, the first non-viral gene expression technology that enables the safe, local, sustained production of therapeutic proteins in the eye to address a wide range of ophthalmic diseases, announces today the appointment of Thierry Bordet, Ph.D. as Pre-Clinical Director.

Thierry will be directing Eyevensys’ pre-clinical development efforts, including the generation of potential clinical candidates for the range of eye diseases that the Company is targeting such as retinal vein occlusion and retinitis pigmentosa. He will also oversee Eyevensys’ relationships with potential academic and industrial partners.

Thierry brings more than 15 years’ experience in the biotechnological sector having managed drug development programs for small molecules, gene therapies, cell-based therapies and tissue engineered products. He was most recently Pre-Clinical Development Director at the Biotherapies Institute for Rare Diseases, in Evry, France where he designed development strategies for advanced therapy medicinal products for various indications, including inherited retinitis pigmentosa. Prior to that he spent 12 years at Trophos managing the company’s drug screening and early development programs for neurodegenerative indications. Thierry has a Ph.D. in microbiology and virology from Pierre & Marie Curie University PARIS VI.

Raffy Kazandjian, CEO of Eyevensys, said, “I am pleased to welcome Thierry to the team. Eyevensys has a unique approach to treating ophthalmic diseases based around our proprietary EyeCET platform. Our objective is to leverage our unique technology to rapidly build a comprehensive portfolio of products that will target a range of major eye diseases; and Thierry’s extensive pre-clinical research experience, as well as years of direct involvement in the development of gene therapies will be a great asset to move several of our products forward.”

Paris (France), 4th September 2017 – Eyevensys, a clinical stage biotech company developing its proprietary EyeCET platform, the first non-viral gene expression technology that enables the safe, local, sustained production of therapeutic proteins in the eye to address a wide range of ophthalmic diseases, announces today the expansion of its executive team with the addition of Dr Ronald R. Buggage as its Chief Medical Officer. Dr Buggage brings more than 14 years’ experience from both large pharma and biotech companies having worked in senior development positions in the US and Europe. Dr Buggage will drive the Company’s drug development strategy, overseeing clinical development programs for a broad range of ophthalmic indications based Eyevensys’ unique non-viral gene therapy EyeCET platform.

Dr Buggage was most recently Division Medical Officer at Sanofi’s Ophthalmology Unit, responsible for the leadership and coordination of medical and scientific activities for its ophthalmology portfolio including development programs for ocular gene therapy. He also served as Chief Scientific Officer of Novagali Pharma, where he was responsible for the global clinical and regulatory strategy; Novagali Pharma was successfully acquired by Santen. Prior to moving to France, Dr Buggage held various positions of increasing clinical development responsibility at Novartis and Pfizer. Dr Buggage obtained his MD at UCLA School of Medicine, specializing in ophthalmology at Emory, and completed his training in ocular immunology and uveitis at the National Eye Institute of the National Institutes of Health (NIH).

Raffy Kazandjian, CEO of Eyevensys, said, “We are delighted to add such an experienced and high-calibre individual to our executive team. Ronald’s unique combination of regulatory, medical, and drug development expertise in the ophthalmic space, including uveitis, will be a major asset as Eyevensys advances its high potential pipeline. This includes our lead product EYS606 for which the first in human phase I/II clinical trial was recently initiated in France.”

He added, “Eyevensys has a unique approach to treating ophthalmic diseases based around our proprietary EyeCET platform that we believe is the only non-viral technology that enables the safe local sustained production of therapeutic proteins in the eye for up to six months. I am confident that our approach will have a clear appeal to physicians and patients, offering them a clearly differentiated alternative to existing treatments for major ophthalmic indications.”

Dr Ronald R. Buggage, CMO of Eyevensys, commented, “I am particularly thrilled to join Eyevensys at such a pivotal time. Its proprietary EyeCET platform offers an innovative approach to sustained intraocular drug delivery which combined with the non-viral delivery of the plasmids provides a convenient alternative to current biologics used to treat ophthalmic diseases. I believe that with EyeCET, Eyevensys has the potential to build an exciting, high value pipeline of new ocular therapies.”