Posts By :

admin

Pharmtech Focus: Eyevensys Raises $12M in a Series B Plus Funding Round

Pharmtech Focus: Eyevensys Raises $12M in a Series B Plus Funding Round 150 150 Eyevensys

The $12M raised in a Series B Plus funding round will support development of Eyevensys’s EYS809 program for the treatment of wet age-related macular degeneration (AMD), a chronic eye disorder that causes blurred vision or a blind spot in the eye.

WSJ Pro VC Daily: Biotech Acquisitions Could Be Poised for Second-Half Rebound

WSJ Pro VC Daily: Biotech Acquisitions Could Be Poised for Second-Half Rebound 150 150 Eyevensys

Paris- and Cambridge, Mass.-based biotech company developing therapies for ophthalmic diseases raised $12 million in Series B+ funding, led by Korea Investment Partners.

Eyevensys Raises $12M in a Series B Plus Funding Round

Eyevensys Raises $12M in a Series B Plus Funding Round 1920 1277 Eyevensys

Paris, France, and Cambridge, Mass., United States, August 04, 2021 – Eyevensys, a privately held, clinical-stage biotechnology company developing non-viral gene therapies for ophthalmic diseases, today announces it has raised $12M in a Series B Plus funding round. Korea Investment Partners is leading the Series B Plus financing and existing investors will also join the round.  

The financing will support Eyevensys’ accelerated development of its EYS809 program for the treatment of wet age-related macular degeneration (AMD), a chronic eye disorder that causes blurred vision or a blind spot in the eye. The condition accounts for approximately 90 percent of all AMD-related blindness. Additionally, the company will advance its EYS611 program targeting geographic atrophy (GA) and retinitis pigmentosa.

The Eyevensys technology is a non-viral gene therapy ocular drug delivery platform that uses an Electrotransfection System to deliver DNA plasmids encoding therapeutic proteins into the ciliary muscle to sustainably treat major eye diseases. This turns the eye into a biofactory, allowing the ciliary muscle to express and secrete the therapeutic protein to the back of the eye at therapeutic levels for a duration of greater than 6 months.

Eyevensys has validated its electrotransfection technology in the clinic through its EYS606 program for non-infectious uveitis, a sight-threatening intraocular inflammatory condition characterized by inflammation of the uvea. This same Electrotransfection System will be used to deliver relevant therapeutic proteins to the eye for Eyevensys’ other EYS809 and EYS611 programs.

“We’re thrilled to announce this funding round, which will help us move forward in our mission to develop life-changing solutions for patients with debilitating eye diseases,” said Dr. Patricia Zilliox, CEO of Eyevensys. “We are also excited to have the support of Korea Investment Partners and our existing investors as we pivot to refocus on our additional programs focused on wet AMD and retinitis pigmentosa. This funding will allow us to demonstrate that treating ophthalmic conditions doesn’t have to be invasive and risky, and that our approach is more convenient than other intraocular drug delivery approaches.”

Sangwoo Lee, Managing Director of Korea Investment Partners, said: “Eyevensys’ non-viral gene therapy platform is both highly innovative and meets important medical needs. We are thrilled to join Eyevensys in advancing its mission to treat eye diseases.”

Wedbush PacGrow acted as the exclusive placement agent for the Series B Plus financing. 

About Korea Investment Partners

Korea Investment Partners (KIP) is South Korea’s leading venture capital and private equity firm with over 35 years of experience investing in bold and innovative entrepreneurs who want to change the world. KIP manages over 20 venture and private equity funds with over $3.3 billion AUM. The company operates globally from its Seoul headquarters office with other locations in the US, China, and Singapore. 

http://www.kipvc.com

About Eyevensys

Eyevensys is a privately held, clinical-stage biotechnology company developing its innovative technology to enable the sustained intraocular production of therapeutic proteins to treat a broad range of ophthalmic diseases.

The Eyevensys technology, developed by Pr. Francine Behar-Cohen, uses electroporation to deliver proprietary DNA plasmids encoding therapeutic proteins into the ciliary muscle of the eye. This approach induces the sustained intraocular production of therapeutic proteins.

Eyevensys is advancing a dual gene plasmid, EYS809, expressing two therapeutic proteins, a potent VEGF inhibitor and an endogenous protein with anti-angiogenic and antifibrotic properties for the treatment of wet AMD which also has the potential be a treatment for diabetic retinopathy, diabetic macular edema and central retinal vein occlusion.

Eyevensys is also developing EYS611, a treatment for the later stages of dry AMD and for retinitis pigmentosa and potentially other retinal degenerative conditions including glaucoma. The treatment encodes for a potent iron chelator with antioxidant and endogenous neuroprotective properties. In animal models, the treatment has been shown to be safe and effective at slowing the degeneration of retinal structure and preserving function. EYS611 has been granted Orphan drug designation for the treatment of retinitis pigmentosa in the EU and in the US.

Additionally, Eyevensys has developed EYS606 as a potential new treatment for patients with chronic non-infectious uveitis (NIU). The therapy has been used to validate the proprietary Electrotransfection System, which in the case of EYS606, is combined with plasmids encoding for the production of a potent fusion protein which neutralizes the activity of TNFα, a cytokine that has been shown to play a pivotal role in mediating intraocular inflammation in NIU. EYS606 has been granted an orphan drug designation by the European Medicines Agency (EMA) for the treatment of NIU.

Eyevensys was founded in 2008. The company has offices in Paris, France and the U.S. The company is funded by the Boehringer Ingelheim Venture Fund, Pureos Bioventures, Bpifrance through the Innobio Fund, Karista, Inserm Transfert Initiative, Pontifax and the Global Health Sciences Fund.

For more information about Eyevensys, please visit www.eyevensys.com.

Media Relations Contact:

Jeanene Timberlake
RooneyPartners
jtimberlake@rooneypartners.com
+1 646.770-8858

GeneTherapyLive: Non-Viral Gene Therapy Eases Treatment Burden in Wet AMD

GeneTherapyLive: Non-Viral Gene Therapy Eases Treatment Burden in Wet AMD 150 150 Eyevensys

A non-viral gene therapy sustained drug-delivery product that delivers anti-VEGF to the eye may replace the need for repeated intravitreal anti-VEGF injections and improve vision in patients with wet AMD.

Can Gene Therapy Cure Blindness?

Can Gene Therapy Cure Blindness? 150 150 Eyevensys

LABIOTECH.eu reports on Eyevensys and other innovative companies developing gene therapy treatments with the potential to cure different forms of genetic blindness.

Women Worldwide Podcast: How Are You Innovating in Your Role?

Women Worldwide Podcast: How Are You Innovating in Your Role? 150 150 Eyevensys

Eyevensys CEO, Patricia Zilliox, discusses innovation as a key component of growth in the medical and pharmaceutical industry, what her work has taught her about fundraising, and the impact of the pandemic on her work.

OIS: Francine Behar-Cohen Presents “Innovative Non-Viral Therapies for the Treatment of Ocular Diseases”

OIS: Francine Behar-Cohen Presents “Innovative Non-Viral Therapies for the Treatment of Ocular Diseases” 150 150 Eyevensys

Watch Eyevensys Founder and Chief Innovation Officer, Prof. Francine Behar-Cohen, present at the OIS Ocular Drug Delivery Meeting, providing details about our innovative non-viral gene therapies for the treatment of ocular diseases and our active pipeline and strategy.

OIS Drug Delivery Innovation Showcase – Eyevensys from Healthegy on Vimeo.

Le Figaro: Eyevensys, the Ray of Hope for Treating Ophthalmological Diseases

Le Figaro: Eyevensys, the Ray of Hope for Treating Ophthalmological Diseases 150 150 Eyevensys

Eyevensys founder, Francine Behar-Cohen, and Scientific Director, Thierry Bordet talk to Le Figaro about the company’s innovative treatments and technology in development for treating eye diseases. (article and video)

Eyevensys Receives FDA Orphan Drug Designation for EYS611 for Treatment of Retinitis Pigmentosa

Eyevensys Receives FDA Orphan Drug Designation for EYS611 for Treatment of Retinitis Pigmentosa 1920 1080 Eyevensys

Paris, France, and Cambridge, Mass., United States, October 05, 2020 – Eyevensys, a privately held, clinical-stage biotechnology company developing non-viral gene therapies for ophthalmic diseases, today announced the U.S. Food and Drug Administration (FDA) has granted an orphan-drug designation (ODD) for EYS611 for the treatment of retinitis pigmentosa (RP).  

Eyevensys is developing EYS611, a DNA plasmid that encodes for the human transferrin protein, to benefit patients diagnosed with RP, as well as other degenerative retinal diseases, including late stage, dry age-related macular degeneration and glaucoma.  

Transferrin is an endogenous protein that helps manage iron levels in the eye. While iron is essential for retinal metabolism and the visual cycle, excessive iron can induce oxidative stress and is extremely toxic to the retina. Iron overload has been associated with photoreceptor death in several retinal degenerative diseases. By acting as an iron chelating and neuroprotective agent, EYS611 helps slow the progression of diseases like RP regardless of the specific genetic mutation causing the condition.  

Eyevensys just reported data from preclinical testing in the September 2020 issue of the journal Pharmaceutics. The paper, entitled “Transferrin non-viral gene therapy for treatment of retinal degeneration” (Bigot, et al., Pharmaceutics), shows that EYS611 is safe and effective for preserving photoreceptors and retina functionality in acute toxicity and inherited rat models of retinal degeneration. 

“We are delighted to have received orphan-drug designation from the FDA as it is an important regulatory milestone. We look forward to translating our unique non-viral gene therapy program to patients with RP, to slow the progression of this degenerative retinal disease with no currently approved treatment that compromises patients’ vision and eventually lead to blindness,” said Thierry Bordet, PhD, Chief Scientific Officer.  

“This orphan-drug designation acknowledges the unmet needs of individuals suffering from RP, and this opportunity to move our therapy through the development process with this designation is an encouraging milestone. With EYS611, we are optimistic we will advance a therapeutic option for all patients with RP independent of the underlying genetic mutation that is much less invasive and can be used to treat patients at an earlier stage of disease than traditional viral vector gene replacement therapies that target only the macula and are being developed only for a select handful of RP patients with specific mutations,” said Ronald Buggage, MD, Eyevensys’ Chief Medical Officer.  

The FDA’s Orphan Drug Designation Program provides orphan status to drugs and biologics that are defined as those intended for the safe and effective treatment, diagnosis or prevention of rare diseases/disorders that affect fewer than 200,000 people in the U.S., or that affect more than 200,000 persons but are not expected to recover the costs of developing and marketing a treatment drug.  

About Eyevensys 

Eyevensys is a privately held, clinical-stage biotechnology company developing its innovative technology to enable the sustained intraocular production of therapeutic proteins to treat a broad range of ophthalmic diseases. 

The Eyevensys technology, developed by Pr. Francine Behar-Cohen, uses electroporation to deliver proprietary DNA plasmids encoding therapeutic proteins into the ciliary muscle of the eye. This approach induces the sustained intraocular production of therapeutic proteins. 

Eyevensys’ lead product EYS606 is a potential new treatment for patients with chronic non-infectious uveitis (NIU). EYS606 combines Eyevensys’ proprietary Electrotransfection System with plasmids encoding for the production of a potent fusion protein which neutralizes the activity of TNFα, a cytokine that has been shown to play a pivotal role in mediating intraocular inflammation in NIU. EYS606 is currently in a phase I/II clinical trial in the EU and has been granted an Orphan drug designation by the European Medicines Agency (EMA) for the treatment of NIU. The therapeutic potential of EYS606 in patients with active, chronic NIU is being further investigated in Part 2 of the ongoing EYS606-CT1 study in the EU and in a second phase 2 trial, the Electro Study (EYS606-CT2) being conducted in the US. 

Additionally, Eyevensys is developing EYS611, a treatment for Retinitis Pigmentosa and potentially other retinal degenerative conditions including the later stages of Dry AMD and glaucoma. The treatment encodes for a potent iron chelator with antioxidant and endogenous neuroprotective properties. In animal models, the treatment has been shown to be safe and effective at preserving and slowing the degeneration of retinal structure and function. 

Eyevensys is also advancing a dual gene plasmid, EYS809, expressing two therapeutic proteins for wet AMD, diabetic macular edema, and central retinal vein occlusion, and it is exploring further compounds for undisclosed indications. 

Eyevensys was founded in 2008. The company has offices in Paris, France and the U.S. The company is funded by the Boehringer Ingelheim Venture Fund, Pureos Bioventures, Bpifrance through the Innobio Fund, CapDecisif, Inserm Transfert Initiative, Pontifax and the Global Health Sciences Fund. 

For more information about Eyevensys, please visit www.eyevensys.com

Media Relations Contact:
Marion Janic, RooneyPartners
mjanic@rooneyco.com
+1-212-223-4017 

OIS: Eyevensys CEO, Patricia Zilliox, Featured on OIS Retina Podcast

OIS: Eyevensys CEO, Patricia Zilliox, Featured on OIS Retina Podcast 150 150 Eyevensys

Listen to Patricia Zilliox, CEO of Eyevensys, discuss her background, her industry experience and expertise, and her passion for developing treatments to improve patient outcomes.